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Daily tadalafil: 2.5- or 5-milligram (mg) daily pill; Tadalafil: 5 mg, 10 mg, or 20 mg, According to the United Kingdom s National Health Service, Cialis can last up to 36 hours Tadalafil is a medicine that relaxes blood vessels and treats erectile dysfunction and pulmonary hypertension. Cialis is a brand of tadalafil that can be taken up to 36 hours before sexual activity. cialis 36 hour pill Find everything you need to know about Cialis (Tadalafil), including what it is used for, warnings, reviews, side effects, and interactions. Learn more about Cialis (Tadalafil) at EverydayHealth.com. The active substance of Cialis, tadalafil, belongs to a group of medicines called ‘phosphodiesterase type 5 (PDE5) inhibitors’. It works by blocking the phosphodiesterase enzyme, which normally breaks down a substance known as cyclic guanosine monophosphate (cGMP). For once-a-day Cialis, try to schedule the daily dose at the same time each day. For erectile dysfunction, sexual activity can be initiated any time from 30 minutes to 36 hours after taking Cialis. For erectile dysfunction, sexual stimulation is required for Cialis to show benefits.